News Archive - GOG https://www.gog.org/news/ Gog Thu, 29 Jan 2026 20:55:41 +0000 en-US hourly 1 https://wordpress.org/?v=6.9 Accrual Culture: Top Points for Site Selection – Enrollement https://www.gog.org/news/accrual-culture-top-points-for-site-selection-enrollement/ Thu, 29 Jan 2026 20:55:41 +0000 https://www.gog.org/?post_type=news&p=8570 The GOG’s Accrual Culture series—Top Points for Site Selection—is available now! Access this new episode here: Access on GOG GYN-LIVE Podcast Access […]

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The GOG’s Accrual Culture series—Top Points for Site Selection—is available now!

Access this new episode here:

Access on GOG GYN-LIVE Podcast

Access on YouTube

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GOG GYN-LIVE PODCAST https://www.gog.org/news/gog-gyn-live-podcast/ Thu, 29 Jan 2026 20:46:57 +0000 https://www.gog.org/?post_type=news&p=8566 The GOG GYN-LIVE Podcast is available now! Welcome to the official podcast of The GOG Foundation, Inc.—a nonprofit organization dedicated […]

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The GOG GYN-LIVE Podcast is available now!

Welcome to the official podcast of The GOG Foundation, Inc.—a nonprofit organization dedicated to advancing excellence in clinical and scientific research for gynecologic cancers. From ovarian and uterine to cervical, vaginal, and vulvar malignancies, our investigators and institutions are at the forefront of innovation, shaping the future of cancer care.

 

Each episode features leading experts, groundbreaking trial insights, and real-world stories that illuminate the evolving landscape of gynecologic oncology. Whether you’re a clinician, researcher, patient advocate, or survivor, join us as we explore the science, the people, and the progress driving better outcomes and quality of life for patients everywhere.

 

Subscribe and List

 

Listen to GOG GYN-LIVE using one of many popular podcasting apps or directories.

 

 

Click here to access the GOG GYN-LIVE Podcast website page.

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ROSELLA GOG-3073 | ENGOT-OV72Press Release https://www.gog.org/news/rosella-gog-3073-engot-ov72press-release/ Thu, 22 Jan 2026 21:07:23 +0000 https://www.gog.org/?post_type=news&p=8556 PRESS RELEASE For Immediate Release Overall Survival Primary Endpoint Met in Corcept’s Pivotal Phase 3 ROSELLA Trial of Relacorilant in […]

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PRESS RELEASE

For Immediate Release

Overall Survival Primary Endpoint Met in Corcept’s Pivotal Phase 3 ROSELLA Trial of Relacorilant in Patients with Platinum-Resistant Ovarian Cancer


REDWOOD CITY, Calif.–(BUSINESS WIRE)–Jan. 22, 2026– Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, today announced that ROSELLA, the company’s pivotal Phase 3 trial of relacorilant plus nab-paclitaxel to treat patients with platinum-resistant ovarian cancer, met its overall survival (OS) primary endpoint.

Click here to read full press release.

 

 

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GOG Partners Connection Quarterly Newsletter – December 2025 https://www.gog.org/news/gog-partners-connection-quarterly-newsletter-september-2025-2/ Tue, 23 Dec 2025 16:55:56 +0000 https://www.gog.org/?post_type=news&p=8509 The GOG Partners Connection Quarterly Newsletter is now available! Click here to download a PDF copy of the GOG Partners […]

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The GOG Partners Connection Quarterly Newsletter is now available!

Click here to download a PDF copy of the GOG Partners Connection Newsletter.

 

 

 

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GOG-3133/ FRAmework-01/ ENGOT-ov97/ GINECO-NOGGO Press Release https://www.gog.org/news/gog-3133-framework-01-engot-ov97-gineco-noggo-press-release/ Tue, 09 Dec 2025 20:47:10 +0000 https://www.gog.org/?post_type=news&p=8477 PRESS RELEASE For Immediate Release Philadelphia, PA, USA, December 9, 2025, First Patient Enrolled in GOG-3133/ FRAmework-01 Phase 3 Study […]

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PRESS RELEASE

For Immediate Release

Philadelphia, PA, USA, December 9, 2025, First Patient Enrolled in GOG-3133/ FRAmework-01 Phase 3 Study Evaluating Sofetabart Mipitecan (LY4170156), a Novel ADC Targeting Folate Receptor Alpha (FRα), in Recurrent Ovarian Cancer

The GOG Foundation, Inc. is proud to announce the enrollment of the first patient in GOG-3133, a pivotal Phase 3 clinical trial titled FRAmework-01: A Two-Part Phase 3 Study of LY4170156 versus Chemotherapy or Mirvetuximab Soravtansine in Platinum-Resistant Ovarian Cancer, and LY4170156 plus Bevacizumab versus Platinum-Based Chemotherapy plus Bevacizumab in Platinum-Sensitive Ovarian Cancer. The study is sponsored by Eli Lilly and Company and conducted in collaboration with The GOG Foundation, Inc.

Click here to read full press release.

 

 

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GOG Partners Connection Quarterly Newsletter – September 2025 https://www.gog.org/news/gog-partners-connection-quarterly-newsletter-september-2025/ Thu, 16 Oct 2025 18:09:47 +0000 https://www.gog.org/?post_type=news&p=8370 The GOG Partners Connection Quarterly Newsletter is now available! Click here to download a PDF copy of the GOG Partners […]

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The GOG Partners Connection Quarterly Newsletter is now available!

Click here to download a PDF copy of the GOG Partners Connection Newsletter.

 

 

 

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Expert Review of Anticancer Therapy: GOG-3083/ENGOT-EN-20/XPORT-EC-042 Publication https://www.gog.org/news/expert-review-of-anticancer-therapy-gog-3083-engot-en-20-xport-ec-042-publication/ Mon, 15 Sep 2025 15:41:15 +0000 https://www.gog.org/?post_type=news&p=8248 PUBLICATION An evaluation of selinexor as a maintenance therapy for patients with p53 wild-type, advanced, or recurrent endometrial carcinoma   […]

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PUBLICATION


An evaluation of selinexor as a maintenance therapy for patients with p53 wild-type, advanced, or recurrent endometrial carcinoma
 

ABSTRACT
Introduction: Tumor protein 53 gene (TP53) is the most frequently mutated gene in human cancers.
TP53 mutation status may have prognostic value across malignancy types, and its use as a predictive
biomarker is limited. Selinexor is a novel oral exportin 1 (XPO1) inhibitor with preliminary efficacy data
as a maintenance treatment in advanced/recurrent TP53 wild-type (wt) endometrial cancer (EC),
suggesting TP53wt may be a predictive biomarker for this therapy. XPO1 mediates nuclear to cytoplasmic
trafficking of transcriptionally active p53, where it is degraded and rendered functionally
inactive. Selinexor prevents this export to restore nuclear p53 and increase the transcription of p53
activated target genes.


Areas covered: This review examines the mechanism of action of selinexor related to p53, contextualizes
the effectiveness of selinexor among EC subtypes within the context of the evolving diagnostic,
predictive, and therapeutic landscape for treatment, and presents the relevant clinical studies for
selinexor dose for its use in gynecological malignancies. Literature review was conducted on the
PubMed database.


Expert opinion: The promising efficacy signal suggests selinexor has potential as a maintenance
therapy for TP53wt EC to address current treatment gaps. A phase

 

Click here to read the full publication.

 

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]]> GOG Partners Connection Quarterly Newsletter – July 2025 https://www.gog.org/news/gog-partners-connection-quarterly-newsletter-july-2025/ Mon, 11 Aug 2025 21:55:32 +0000 https://www.gog.org/?post_type=news&p=8100 The GOG Partners Connection Quarterly Newsletter is now available! Click here to download a PDF copy of the GOG Partners […]

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The GOG Partners Connection Quarterly Newsletter is now available!

Click here to download a PDF copy of the GOG Partners Connection Newsletter.

 

 

 

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The GOG Foundation and EVA/LACOG Partnership: A Collaborative Strategic Alliance for Clinical Trial Execution Publication https://www.gog.org/news/the-gog-foundation-and-eva-lacog-partnership-a-collaborative-strategic-alliance-for-clinical-trial-execution-publication/ Fri, 01 Aug 2025 21:48:19 +0000 https://www.gog.org/?post_type=news&p=8042 PUBLICATION The GOG Foundation and EVA/LACOG partnership: a collaborative strategic alliance for clinical trial execution The collaborative efforts between GOG […]

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PUBLICATION
The GOG Foundation and EVA/LACOG partnership: a collaborative strategic alliance for clinical trial execution


The collaborative efforts between GOG and LACOG are aimed at advancing clinical oncology research through strategic global partnerships, particularly related to the conduct of clinical trials. Herein, we provide the framework of this relationship addressing key operational components including establishing a shared Publication Policy. In addition, this initiative seeks to standardize contributions, recognize authorship fairly, and ensure compliance with agreed protocols. Emphasis is placed on critical practices like study design, data interpretation, manuscript development, and intellectual review. The Policy considers the roles of individual scientists, institutional sponsors, and contributors while ensuring transparency and authenticity in scientific communication. This collaborative approach underscores the importance of collective expertise in addressing global challenges in oncology and fostering innovation through multi-institutional cooperation. The manuscript outlines the processes for critical review, approval, and publication, ensuring credibility in the dissemination of scientific findings to the community. These frameworks aim to promote inclusivity, equitable representation, and the advancement of oncology knowledge.


Click here to read the full publication.

 

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IJGC GOG Foundation Scholar Career Development Award and New Investigator Program Publication https://www.gog.org/news/ijgc-gog-foundation-scholar-career-development-award-and-new-investigator-program-publication/ Fri, 11 Jul 2025 21:28:50 +0000 https://www.gog.org/?post_type=news&p=7919 PUBLICATION Expanding the workforce of clinical trial investigators committed to gynecologic cancer research: The GOG Foundation, Inc’s Scholar Career Development Award […]

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PUBLICATION

Expanding the workforce of clinical trial investigators committed to gynecologic cancer research: The GOG Foundation, Inc’s Scholar Career Development Award and New Investigator Program

HIGHLIGHTS

  • Gynecologic Oncology Group Foundation, Inc (GOG-F) Scholars and New Investigators collectively enrolled over 3,100 patients in clinical trials, published more than 1000 scholarly works, and obtained greater than $150 million in subsequent funding.
  • The GOG-F Scholar and New Investigator programs offer a scalable and pragmatic model for developing the clinical trial workforce.

Click here to read the full publication.

 

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