Optimizing Treatment Decisions in Platinum-Resistant Ovarian Cancer: Evidence, Sequencing, and Understanding Patient-Centered Care Through Case-Based Learning

Activity Overview

Platinum-resistant ovarian cancer (PROC) remains an area of significant unmet need, where treatment goals focus on prolonging survival while preserving quality of life. As new therapies emerge and the treatment landscape rapidly evolves, clinicians must navigate increasingly complex decisions regarding biomarker testing, treatment sequencing, efficacy expectations, toxicity management, and patient preferences.  This highly interactive, case-based educational program will begin with a competitive landscape update reviewing available and emerging therapies in PROC, including efficacy benchmarks, safety considerations, and evolving clinical evidence. Faculty will then guide participants through real-world patient scenarios that explore biomarker-driven and biomarker-agnostic decision-making, sequencing strategies, management of treatment-related adverse events, and practical treatment selection considerations. Throughout the discussion, faculty will examine how recent and emerging data may influence future standards of care and improve the patient experience.   The program will emphasize translating evidence into practice, helping clinicians present the best treatment options for their patients.  

The GOG Foundation, Inc. is grateful for our commercial supporter for their unrestricted educational grant associated with this Symposium: Corcept Therapeutics

Target Audience

The target audience for this activity is community and academic gynecologic oncologists, oncologists, advanced practitioners (NP/PA/PharmD), and other providers who treat patients with gynecologic malignancies.

Learning Objectives

After participating in this activity, learners will be able to: 

  1. Assess the current and emerging treatment landscape for platinum-resistant ovarian cancer, including key efficacy, safety, and patient-centered considerations. 
  2. Evaluate the role of biomarkers and molecular testing in treatment selection and understand emerging evidence regarding their predictive utility. 
  3. Apply available clinical trial data to treatment sequencing decisions through evidence-based case discussions. 
  4. Develop strategies for managing treatment-related adverse events while maintaining quality of life in patients with PROC. 
  5. Incorporate evolving evidence into individualized treatment plans through scenario-based clinical decision making. 

Moderator

Shannon Westin, MD, MPH

The University of Texas MD Anderson Cancer Center

Faculty

Thomas Krivak, MD

Allegheny West Penn Hospital - Allegheny Health Network

Domenica (Ketta) Lorusso, MD, PhD

Humanitas University, Pieve Emanuele, Humanitas San Pio X Hospital

Agenda

13:05 - 13:10
Welcome and Audience Polling

Shannon Westin, MD, MPH
The University of Texas MD Anderson Cancer Center

13:10 - 13:25
Competitive Landscape Update: Where Are We Today in PROC? Faculty Presentation

Domenica Lorusso, MD, PhD
Humanitas University, Pieve Emanuele, Humanitas San Pio X Hospital

13:25 - 13:37
Case 1: Does the Biomarker Matter?

Thomas Krivak, MD
Allegheny West Penn Hospital - Allegheny Health Network

13:37 - 13:49
Case 2: Sequencing Therapy in Clinical Practice

Domenica Lorusso, MD, PhD
Humanitas University, Pieve Emanuele, Humanitas San Pio X Hospital

13:49 - 14:01
Case 3: Patient Experience and Adverse Event Management

Faculty: Dr. Westin, Dr. Krivak, Dr. Lorusso

14:01 - 14:15
Expert Panel: What Happens Next?

Shannon Westin, MD, MPH
The University of Texas MD Anderson Cancer Center